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Babesia infection is often asymptomatic or associated with mild, nonspecific symptoms. The infection can also be severe and life threatening, particularly in people who are asplenic, immunocompromised, or elderly. When symptomatic, babesiosis, like malaria, is characterized by fever and hemolytic anemia. Clinical manifestations of babesiosis include malaise, anorexia, and fatigue, followed by fever, chills, sweats, myalgia, arthralgia, headache, and nausea. Severe babesiosis may require hospitalization for management of marked anemia, adult respiratory distress syndrome, disseminated intravascular coagulation, renal impairment, shock, or splenic rupture. Congenital infection with nonspecific manifestations suggestive of sepsis has been reported.

Babesiosis should be considered in a...

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