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23: Burkholderia Infections
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Published:January 2023
"Burkholderia Infections", Red Book Atlas of Pediatric Infectious Diseases, Tina Q. Tan, MD, FAAP
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Species within the Burkholderia cepacia complex have been primarily associated with infections in individuals with cystic fibrosis (CF) or chronic granulomatous disease (CGD). Infections have also been reported in people with hemoglobinopathies and malignant neoplasms and in preterm infants. Airway infections of B cepacia in people with CF usually occur later in the course of disease, after respiratory epithelial damage and bronchiectasis have occurred. Patients with CF can become chronically infected with little change in the rate of pulmonary decompensation, or they can experience an accelerated decline in pulmonary function or an unexpectedly rapid deterioration in clinical status that results...