100: Parechovirus Infections

Parechoviruses (PeVs) primarily cause disease in young infants and manifest in a similar manner to that of enterovirus, disseminated herpes simplex virus, or bacterial infections, with a febrile illness, exanthem (maculopapular and/or generalized erythema or erythroderma, often with palmar and plantar erythema and at times in a distribution limited to the hands and feet), sepsis-like syndrome (frequently with leukopenia), and/or central nervous system (CNS) manifestations. CNS manifestations include meningitis (typically with little or no pleocytosis), encephalitis, seizures, and apnea, often with brain imaging abnormalities primarily affecting white matter; long-term neurodevelopmental sequelae may occur. Infections (particularly with PeV-A3) may be severe,...