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117: Rabies
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Published:January 2023
"Rabies", Red Book Atlas of Pediatric Infectious Diseases, Tina Q. Tan, MD, FAAP
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Infection with rabies virus and other lyssaviruses characteristically produces an acute illness with rapidly progressive central nervous system manifestations, including anxiety, radicular pain, dysesthesia or pruritus, hydrophobia, and dysautonomia. Some patients may have paralysis. Illness almost invariably progresses to death. The differential diagnosis of acute encephalitic illnesses of unknown cause or with features of Guillain-Barré syndrome should include rabies.
Rabies virus is a single-stranded RNA virus classified in the Rhabdoviridae family, Lyssavirus genus. The genus Lyssavirus currently contains 14 species divided into 3 phylogroups.
Understanding the epidemiology of rabies has been aided by viral variant identification with monoclonal antibodies and...