Gluten-Sensitive Enteropathy (Celiac Sprue) (Chapter 259)
Anca M. Safta, MD, John A. Kerner, Jr, MD, 2016. "Gluten-Sensitive Enteropathy (Celiac Sprue) (Chapter 259)", American Academy of Pediatrics Textbook of Pediatric Care, Thomas K. McInerny, MD, FAAP, Henry M. Adam, MD, FAAP, Deborah E. Campbell, MD, FAAP, Thomas G. DeWitt, MD, FAAP, Jane Meschan Foy, MD, FAAP, Deepak M. Kamat, MD, PhD, FAAP, Rebecca Baum, MD, FAAP, Kelly J. Kelleher, MD, MPH, FAAP
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Celiac disease (CD), also known as celiac sprue or gluten-sensitive enteropathy (GSE), is a condition characterized by clinical features of malabsorption and pathologic changes in the jejunal mucosa, both of which improve when gluten is removed from the diet and recur when it is reintroduced. CD is the second most common cause of malabsorption in children, the most common being cystic fibrosis. Even though CD is characterized by malabsorption, the disease is extremely protean in its manifestations and many children with CD may not have features of overt malabsorption.
The classic clinical description of CD was first provided in 1888....