Hemolytic-Uremic Syndrome (Chapter 263)
Horacio Esteban Adrogue, MD, Joseph Angelo, MD, 2016. "Hemolytic-Uremic Syndrome (Chapter 263)", American Academy of Pediatrics Textbook of Pediatric Care, Thomas K. McInerny, MD, FAAP, Henry M. Adam, MD, FAAP, Deborah E. Campbell, MD, FAAP, Thomas G. DeWitt, MD, FAAP, Jane Meschan Foy, MD, FAAP, Deepak M. Kamat, MD, PhD, FAAP, Rebecca Baum, MD, FAAP, Kelly J. Kelleher, MD, MPH, FAAP
Download citation file:
Hemolytic-uremic syndrome (HUS) is a systemic thrombotic microangiopathy clinically defined by the classic triad of nonimmune microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury. The underlying pathologic process in HUS results in vascular endothelial injury leading to arteriolar-capillary occlusive lesions formed by platelet-fibrin thrombi. While the kidney is the most common and clinically significant site of injury, multiple organ systems including the central nervous system, gastrointestinal tract, heart, lungs, and pancreas can be affected. Broadly, HUS is categorized into 2 types. HUS that follows diarrheal illness or is related to specific infectious agents is designated as typical or D+HUS,...