Guidelines for the treatment of Lyme arthritis were published by the Infectious Diseases Society of America in 2006 and recommended oral doxycycline for initial therapy. We report here the case of a young girl treated with intravenous ceftriaxone who subsequently developed drug-induced autoimmune hemolytic anemia and renal failure. Her severe sequelae highlight the importance of antimicrobial stewardship. We review here the goals of antimicrobial stewardship and several strategies for achieving them. In addition, we briefly discuss the rare adverse drug event experienced by our patient.
Subjects:
Adolescent Health/Medicine
Copyright © 2011 by the American Academy of Pediatrics
2011
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Comments
Additional Cases of Ceftriaxone-Induced Hemolysis
The lessons pertaining to antimicrobial stewardship, accompanying the case report of ceftriaxone-induced hemolysis, offered by Dr. Boggs and her colleagues are important ones. We really appreciate the authors' review of previously published cases of hemolytic anemia from ceftriaxone, but wish the end-date of the medical literature search ("since 1991") had been provided. To aid future scholars reading the paper by Boggs et al., we would like to add our recently published clinical reports to the reference pool (Goyal M, et al. Severe hemolytic crisis after ceftriaxone administration. Pediatr Emerg Care 2011; 27: 322-323.).
Conflict of Interest:
None declared