Human Herpesvirus 6 (Including Roseola) and 7
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Published:2021
2021. "Human Herpesvirus 6 (Including Roseola) and 7", Red Book: 2021–2024 Report of the Committee on Infectious Diseases, Committee on Infectious Diseases, American Academy of Pediatrics, David W. Kimberlin, MD, FAAP, Elizabeth D. Barnett, MD, FAAP, Ruth Lynfield, MD, FAAP, Mark H. Sawyer, MD, FAAP
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Human herpesvirus 6 and 7 comprise 3 distinct viral species, HHV-6B, HHV-6A, and HHV-7. Although many infections are asymptomatic, clinical manifestations of primary infection with human herpesvirus 6B (HHV-6B) include roseola (exanthem subitum) in approximately 20% of infected children as well as a nonspecific febrile illness without rash or localizing signs. Acute HHV-6B infection may be accompanied by cervical and characteristic postoccipital lymphadenopathy, gastrointestinal tract or respiratory tract signs, and inflamed tympanic membranes. Fever may be high (temperature >39.5°C [103.0°F]) and persist for 3 to 7 days. Approximately 20% of all emergency department visits for febrile children 6 through 12...