Nocardiosis
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Published:2021
2021. "Nocardiosis", Red Book: 2021–2024 Report of the Committee on Infectious Diseases, Committee on Infectious Diseases, American Academy of Pediatrics, David W. Kimberlin, MD, FAAP, Elizabeth D. Barnett, MD, FAAP, Ruth Lynfield, MD, FAAP, Mark H. Sawyer, MD, FAAP
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Immunocompetent children typically develop cutaneous or lymphocutaneous disease with pustular or ulcerative lesions following soil contamination of a skin injury. Deep-seated tissue infection may follow traumatic soil-contaminated wounds. Immunocompromised people may develop invasive disease (pulmonary disease, which may disseminate). At-risk people include those with chronic granulomatous disease, chronic obstructive pulmonary disease (COPD), human immunodeficiency virus (HIV) infection, disease requiring long-term systemic corticosteroid/immunosuppressive therapy, solid organ or bone marrow transplantation, autoimmune disease, or people having received tumor necrosis factor inhibitors. Pulmonary disease commonly manifests as rounded nodular infiltrates that can undergo cavitation; the infection may be acute, subacute, or chronic...