Factors Contributing to Resistance
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Published:2021
2021. "Factors Contributing to Resistance", Red Book: 2021–2024 Report of the Committee on Infectious Diseases, Committee on Infectious Diseases, American Academy of Pediatrics, David W. Kimberlin, MD, FAAP, Elizabeth D. Barnett, MD, FAAP, Ruth Lynfield, MD, FAAP, Mark H. Sawyer, MD, FAAP
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The use of antimicrobial agents is a key driver of antimicrobial resistance. Antimicrobial agents are among the most commonly prescribed drugs used in human medicine. Many studies have measured the extent of inappropriate or unnecessary antibiotic use; results have been remarkably consistent at 30% to 50% in both inpatient and outpatient studies.
The number of antibiotic-resistant bacteria and the diversity of molecular mechanisms of resistance continue to increase, but the development of newer, effective antimicrobial agents has not kept pace. The loss of effective antimicrobial agents will hamper clinicians’ efforts to treat potentially life-threatening infections. At the same time, many...