Recommended Antimicrobial Agents
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Published:2021
2021. "Recommended Antimicrobial Agents", Red Book: 2021–2024 Report of the Committee on Infectious Diseases, Committee on Infectious Diseases, American Academy of Pediatrics, David W. Kimberlin, MD, FAAP, Elizabeth D. Barnett, MD, FAAP, Ruth Lynfield, MD, FAAP, Mark H. Sawyer, MD, FAAP
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An antimicrobial agent is chosen on the basis of bacterial pathogens most likely to cause infectious complications during and after the specific procedure, the antimicrobial susceptibility pattern of these pathogens, and the safety and efficacy of the drug. Antimicrobial agents administered prophylactically do not have to be active in vitro against every potential organism to be effective, because it is unlikely that all potential organisms are actually contaminating the wound. Doses are determined on the basis of the need to achieve therapeutic blood and tissue concentrations throughout the procedure. Antimicrobial prophylaxis for most surgical procedures, including gastric, biliary, thoracic (noncardiac),...