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Key Action Statement Profile: KAS 3C

Aggregate evidence quality Grade B 
Benefits Moderately increased likelihood of more rapid resolution of symptoms with initial antibiotics. Moderately increased likelihood of resolution of AOM with initial antibiotics. 
Risks, harms, cost Adverse events attributable to antibiotics, such as diarrhea, diaper dermatitis, and allergic reactions. Overuse of antibiotics leads to increased bacterial resistance. Cost of antibiotics. 
Benefits-harms assessment Moderate degree of benefit over harm. 
Value judgments Observation becomes an alternative as the benefits and harms approach balance. 
Role of patient preference Joint decision-making with the family is essential before choosing observation. 
Intentional vagueness Joint decision-making is highly variable from family to family 
Exclusions None 
Strength Recommendation 
Note In the judgment of 1 Subcommittee member (AH), antimicrobial treatment of these children is preferred because of a preponderance of benefit over harm. AH did not endorse Key Action Statement 3C 
Aggregate evidence quality Grade B 
Benefits Moderately increased likelihood of more rapid resolution of symptoms with initial antibiotics. Moderately increased likelihood of resolution of AOM with initial antibiotics. 
Risks, harms, cost Adverse events attributable to antibiotics, such as diarrhea, diaper dermatitis, and allergic reactions. Overuse of antibiotics leads to increased bacterial resistance. Cost of antibiotics. 
Benefits-harms assessment Moderate degree of benefit over harm. 
Value judgments Observation becomes an alternative as the benefits and harms approach balance. 
Role of patient preference Joint decision-making with the family is essential before choosing observation. 
Intentional vagueness Joint decision-making is highly variable from family to family 
Exclusions None 
Strength Recommendation 
Note In the judgment of 1 Subcommittee member (AH), antimicrobial treatment of these children is preferred because of a preponderance of benefit over harm. AH did not endorse Key Action Statement 3C 
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