Key Action Statement Profile: KAS 4A
| Aggregate evidence quality | Grade B |
| Benefits | Effective antibiotic for most children with AOM. Inexpensive, safe, acceptable taste, narrow antimicrobial spectrum. |
| Risks, harms, cost | Ineffective against β-lactamase–producing organisms. Adverse effects of amoxicillin. |
| Benefits-harms assessment | Preponderance of benefit. |
| Value judgments | Better to use a drug that has reasonable cost, has an acceptable taste, and has a narrow antibacterial spectrum. |
| Intentional vagueness | The clinician must determine whether the patient is truly penicillin allergic. |
| Role of patient preferences | Should be considered if previous bad experience with amoxicillin. |
| Exclusions | Patients with known penicillin allergy. |
| Strength | Recommendation. |
| Aggregate evidence quality | Grade B |
| Benefits | Effective antibiotic for most children with AOM. Inexpensive, safe, acceptable taste, narrow antimicrobial spectrum. |
| Risks, harms, cost | Ineffective against β-lactamase–producing organisms. Adverse effects of amoxicillin. |
| Benefits-harms assessment | Preponderance of benefit. |
| Value judgments | Better to use a drug that has reasonable cost, has an acceptable taste, and has a narrow antibacterial spectrum. |
| Intentional vagueness | The clinician must determine whether the patient is truly penicillin allergic. |
| Role of patient preferences | Should be considered if previous bad experience with amoxicillin. |
| Exclusions | Patients with known penicillin allergy. |
| Strength | Recommendation. |