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Aggregate evidence quality: B
Benefit Diagnosis allows decisions regarding management to be made. Children likely to benefit from antimicrobial therapy will be identified. 
Harm Inappropriate diagnosis may lead to unnecessary treatment. A missed diagnosis may lead to persistent infection or complications 
Cost Inappropriate diagnosis may lead to unnecessary cost of antibiotics. A missed diagnosis leads to cost of persistent illness (loss of time from school and work) or cost of caring for complications. 
Benefits-harm assessment Preponderance of benefit. 
Value judgments None. 
Role of patient preference Limited. 
Intentional vagueness None. 
Exclusions Children aged <1 year or older than 18 years and with underlying conditions. 
Strength Recommendation. 
Aggregate evidence quality: B
Benefit Diagnosis allows decisions regarding management to be made. Children likely to benefit from antimicrobial therapy will be identified. 
Harm Inappropriate diagnosis may lead to unnecessary treatment. A missed diagnosis may lead to persistent infection or complications 
Cost Inappropriate diagnosis may lead to unnecessary cost of antibiotics. A missed diagnosis leads to cost of persistent illness (loss of time from school and work) or cost of caring for complications. 
Benefits-harm assessment Preponderance of benefit. 
Value judgments None. 
Role of patient preference Limited. 
Intentional vagueness None. 
Exclusions Children aged <1 year or older than 18 years and with underlying conditions. 
Strength Recommendation. 
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