Skip to Main Content
Aggregate evidence quality: D; expert opinion and reasoning from first principles.
Benefit Prevention of complications, administration of effective therapy. 
Harm Adverse effects of secondary antibiotic therapy. 
Cost Direct cost of medications, often substantial for second-line agents. 
Benefits-harm assessment Preponderance of benefit. 
Value judgments Clinician must determine whether cost and adverse effects associated with change in antibiotic is justified given the severity of illness. 
Role of patient preferences Limited in patients whose symptoms are severe or worsening, but caregivers of mildly affected children who are failing to improve may reasonably defer change in antibiotic. 
Intentional vagueness None. 
Exclusions None. 
Strength Option. 
Aggregate evidence quality: D; expert opinion and reasoning from first principles.
Benefit Prevention of complications, administration of effective therapy. 
Harm Adverse effects of secondary antibiotic therapy. 
Cost Direct cost of medications, often substantial for second-line agents. 
Benefits-harm assessment Preponderance of benefit. 
Value judgments Clinician must determine whether cost and adverse effects associated with change in antibiotic is justified given the severity of illness. 
Role of patient preferences Limited in patients whose symptoms are severe or worsening, but caregivers of mildly affected children who are failing to improve may reasonably defer change in antibiotic. 
Intentional vagueness None. 
Exclusions None. 
Strength Option. 
Close Modal

or Create an Account

Close Modal
Close Modal